Does regional norepinephrine spillover represent local sympathetic activity?
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چکیده
منابع مشابه
Does regional norepinephrine spillover represent local sympathetic activity?
Regional spillover of norepinephrine (NE), based on isotope dilution and single-compartment steady-state kinetics, is considered one of the best parameters for estimating organ sympathetic activity. However, the effects of local changes in clearance of NE on the spillover have not yet been investigated. We studied local NE kinetics and clearance in the forearm of 10 healthy subjects using intra...
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The analysis of plasma kinetics of the sympathetic neurotransmitter norepinephrine can be used to estimate sympathetic nervous "activity" (integrated nerve firing rate) for the body as a whole and for individual organs. In 12 patients with cardiac failure (left ventricular ejection fraction 10% to 39%), the mean arterial plasma norepinephrine concentration was 557 +/- 68 pg/ml (mean +/- SE) com...
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This study using sampling of blood from the portal vein, in addition to arterial and hepatic sites, to estimate separately spillovers of norepinephrine from mesenteric organs and the liver in seven patients undergoing upper abdominal surgery. Conventional measurements in arterial and hepatic venous plasma provided a measure of net hepatomesenteric NE spillover (403 pmol/ml) that indicated a 13%...
متن کاملRelationship between plasma norepinephrine and sympathetic neural activity.
For circulating norepinephrine (NE) to reflect sympathetic activity validly, plasma NE should show an intensity-dependent increase during sympathetic stimulation and decrease during sympathetic inhibition, and circulating NE should correlate with more directly obtained measures of sympathetic activity. Review of published evidence indicates that NE in peripheral plasma satisfies these criteria....
متن کاملPoint:Counterpoint: Sympathetic activity does/does not influence cerebral blood flow. Point: Sympathetic activity does influence cerebral blood flow.
Cerebral arteries are abundantly innervated by sympathetic fibers, but their influence on cerebral vessels was held unimportant for almost a century (2, 20). Whether there is sympathetic influence on cerebral blood flow (CBF) is important in the management of hypotensive patients. If there is no -adrenergic influence on CBF, a low mean arterial pressure (MAP) can be increased to the cerebral au...
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ژورنال
عنوان ژورنال: Hypertension
سال: 1991
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.18.1.56